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Residence Inn By Marriott Jacksonville-Mayo Clinic Area - Image 1
Residence Inn By Marriott Jacksonville-Mayo Clinic Area - Room
Residence Inn By Marriott Jacksonville-Mayo Clinic Area - Room
Residence Inn By Marriott Jacksonville-Mayo Clinic Area - Reception
Residence Inn By Marriott Jacksonville-Mayo Clinic Area - Pool

Residence Inn By Marriott Jacksonville-Mayo Clinic Area


Amenities

  • Parking

  • Swimming pool

  • Non-Smoking Rooms

  • Business Center

  • Dry Cleaning

  • Housekeeping

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Property description

Be sure to enjoy recreational amenities including an outdoor pool and a 24-hour fitness center. This hotel also features complimentary wireless internet access, concierge services, and wedding services.
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From

$195
/ night

Guest reviews

What guests think

AI-generated summary based on recent guest reviews

Most reviews describe Residence Inn By Marriott Jacksonville-Mayo Clinic Area as very clean and quiet, with friendly, accommodating staff and spacious, well-equipped suites, and a convenient location near the Mayo Clinic with a helpful shuttle.

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Facilities

Good

Cleanliness

Clean

Service

Friendly

Location

Convenient

Was this helpful?

8

arthur

IAN-logo

May 20, 2026

·

Stayed 2 nights

People working on their cars in car park. Unexplained charges made on card after checking out and leaving area
People working on their cars in car park. Unexplained charges made on card after checking out and leaving area

10

Robin

IAN-logo

May 12, 2026

·

Stayed 2 nights

Very clean hotel and nice room. Great breakfast included. Very close to Mayo but not on campus. There used to be a shuttle! I would recommend.
Very clean hotel and nice room. Great breakfast included. Very close to Mayo but not on campus. There used to be a shuttle! I would recommend.

8

Elisa

IAN-logo

May 10, 2026

·

Stayed 2 nights

Very clean Staff friendly and helpful Bed is pretty hard I prefer softer Otherwise everything else's great
Very clean Staff friendly and helpful Bed is pretty hard I prefer softer Otherwise everything else's great

10

Pam

IAN-logo

May 8, 2026

·

Stayed 1 night

Did not eat there
Did not eat there

10

Melody

IAN-logo

May 3, 2026

·

Stayed 2 nights

We enjoyed our stay. Breakfast was good and stocked well. Love the proximity to Mayo Clinic.
We enjoyed our stay. Breakfast was good and stocked well. Love the proximity to Mayo Clinic.

4905 San Pablo Road South, Isle of Palms, Jacksonville Beach, Florida, United States of America

Location

With a stay at Residence Inn By Marriott Jacksonville - Mayo Clinic Area in Jacksonville (Isle of Palms), you'll be a 3-minute drive from Mayo Clinic Florida and 9 minutes from St. Johns Town Center. This hotel is 10.3 mi (16.5 km) from Mayport Naval Station and 5.2 mi (8.4 km) from University of North Florida.

Mayo Clinic Florida(0.9 miles)

Windsor Commons Shopping Center(2.4 miles)

Windsor Parke Golf Club(3.2 miles)

South Beach Park and Sunshine Playground(4 miles)

Atlantic Beach(4.4 miles)

Jacksonville Beach Tennis Center(4.4 miles)

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Property Policies

Check-in instructions

Everything you need to know for a smooth check-in.

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Check-in

Check-out

From 16:00 to 06:00

Before 11:00


Security deposit

You'll be required to pay the fully refundable deposit for this property.

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Good to know

Additional policies and info about this property.

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Optional extras

Additional paid services you can request.

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FAQs

Yes, free self-parking is available on-site. However, parking is limited.


A complimentary buffet breakfast is served on weekdays from 6:30 AM to 9:00 AM and on weekends from 7:00 AM to 9:30 AM.


Yes, pets are allowed with a fee of USD 150 per accommodation, per stay. Service animals are exempt from fees.


Check-in is from 4:00 PM to 11:00 PM, and check-out is by 11:00 AM. Early or late check-in/check-out may be available upon request and could incur additional charges.


The property offers limited wheelchair accessibility, including step-free entrances and accessible facilities in public areas. However, specific details should be confirmed directly with the property.

The hotel is located in Jacksonville (Isle of Palms), just a 3-minute drive from Mayo Clinic Florida and 9 minutes from St. Johns Town Center. It is approximately 10.3 miles from Mayport Naval Station and 5.2 miles from the University of North Florida.


Yes, there is an outdoor heated pool available for guests. The pool is operational seasonally.


Children are welcome at the property. The minimum age for children to stay for free is not specified, so it is advisable to check with the property directly for details.


The property does not specify the availability of extra beds or cribs. It is recommended to contact the property directly for information regarding extra sleeping arrangements.


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