Discover Hotels in the South Loop Area of Houston

Relax at the full-service spa and enjoy the outdoor pool at this luxurious hotel in Houston's Texas Medical Center.

Enjoy an outdoor pool, hot tub, and 24-hour fitness center at this hotel near the Texas Medical Center.

Luxury hotel with outdoor pool, 24-hour fitness center, and multiple dining options near MD Anderson Cancer Center and Houston Zoo.

Enjoy a comfortable stay with an outdoor pool, on-site dining, and a 24-hour fitness center in Houston's South Main area.

Enjoy a stay with an outdoor pool, hot tub, and 24-hour fitness center in Houston's Texas Medical Center.

Enjoy a luxurious stay with an outdoor pool, 24-hour health club, and American cuisine at the on-site restaurant.

Enjoy an outdoor pool and complimentary breakfast at this centrally located hotel near NRG Stadium in Houston.

Hotel with outdoor pool, 24-hour fitness center, and in-house dining near Texas Children's Hospital.

Enjoy spacious rooms with kitchens, an outdoor pool, and complimentary breakfast in the heart of Houston's Medical Center.

Experience luxury at this Houston hotel with an outdoor pool, 24-hour fitness center, and on-site dining options.

Luxury aparthotel with a full-service spa, outdoor pool, and complimentary area shuttle in Houston's Museum District.

Enjoy a family-friendly stay with an outdoor pool, complimentary breakfast, and free area shuttle in Houston's South Main.

Enjoy a luxurious stay with a swimming pool, on-site dining, and a 24-hour fitness center in Houston's Medical Center area.

Enjoy a complimentary breakfast and relax by the outdoor pool at this hotel near the Texas Medical Center.

Comfortable hotel in Houston with free parking, complimentary Wi-Fi, and a convenient area shuttle to nearby attractions.

Enjoy a stay with an outdoor pool, 24-hour fitness center, and complimentary area shuttle in Houston's medical district.

Enjoy a seasonal outdoor pool and fitness center at this centrally located hotel near NRG Park and NRG Stadium.

Comfortable hotel with a 24-hour fitness center and free self-parking near NRG Stadium and NRG Park.

Enjoy a stay with an outdoor pool, 24-hour fitness center, and complimentary breakfast in Houston's medical center.

Enjoy a health club and indoor pool at this hotel near NRG Park and Houston Zoo, perfect for your next stay in Houston.